Change Of Plasma Metabolites In Response To Omega-3 Fatty Acids In Chinese Patients With Type 2 Diabetes: A Double-Blinded Randomized Controlled Trial
FASEB JOURNAL(2015)
Abstract
The objective was to examine the change of metabolites in response to omega‐3 fatty acid supplementation in Chinese diabetic patients. Fifty‐nine patients with type 2 diabetes were randomized into three groups: fish oil (FO, n=20, 50% of C20:5n‐3+C22:6n‐3), flaxseed oil (FLO, n=20, 63% of C18:3n‐3) and corn oil (CO, n=19). The patients consumed corresponding capsules (4 capsules/d) for 6 months. Seventeen healthy subjects without diabetes were recruited as healthy controls (HC) for metabolomic analysis. At baseline, plasma C20:5n‐3 and C22:6n‐3 were significantly lower in diabetic patients compared with HC (P<0.05). FO supplementation significantly increased plasma C20:5n‐3 and C22:6n‐3 (P<0.05), while FLO supplementation significantly increased plasma C18:3n‐3 (P<0.05), compared with CO. In addition, FO intake significantly increased sterol metabolites campesterol and beta‐sitosterol compared with CO (P<0.05). Baseline furan fatty acid metabolite 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoate (CMPF) was significantly lower in diabetic patients compared with HC, while FO supplementation significantly increased plasma CMPF. Baseline plasma C20:5n‐3 was positively correlated with CMPF (r=0.44, P=0.001). In conclusion, fish oil supplementation may have beneficial effects on diabetic patients by increasing tissue n‐3 fatty acid compositions and regulating sterol and furan fatty acid metabolites.
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Key words
fatty acids,diabetes,plasma metabolites,chinese patients
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