Decreased coregulation and interaction of mixed dietary carotenoids when delivered through sequential release technology (645.14)

Carotenoids are implicated as beneficial substances in human health yet human dietary intakes are repeatedly shown to be inadequate to current health recommendations. It may be useful to provide a balanced, naturally derived, mixed carotenoid supplement to address the widespread deficits in carotenoid consumption. However, when mixed carotenoids are delivered into the intestinal tract together considerable competition occurs for micelle formation and subsequent intestinal absorption, affecting the bioavailability of the compounds. Previously we have demonstrated a mixed carotenoid formulation that can release individual carotenoids in a sequential structure over the transit time of the human upper gastrointestinal system (6 hours). We hypothesized that temporally separating the individual carotenoids would reduce competition for micelle formation, improve uptake, and maximize efficacy. Here, we test this hypothesis by evaluating the change of carotenoid levels in the plasma chylomicron fraction for 8 hours after oral doses of a sequential release mixed carotenoid formulation in comparison to a matched conventional release formulation, in a randomized, double blind, repeated measure, cross‐over study in adult humans. We find the carotenoid change from baseline area under the curve (AUC) is more favorable following consumption of the sequential release format over that seen following the conventional release. Spearman’s correlation analysis also demonstrates less interaction and regulation between the sequentially spaced carotenoids, suggesting improved bioavailability from a novel sequential release mixed carotenoid formulation. Grant Funding Source : Supported by Amway Corporation