The Deleterious Effects Of Hyperglycemia On Platelet Function In Diabetic Patients With Acute Coronary Syndrome: Mediation By Superoxide Production, Resolution With Intensive Insulin Administration

A component of platelet dysfunction in diabetic patients with ACS is impaired responsiveness to the anti-aggregatory effects of NO, probably reflecting increased NO clearance by O2-. This phenomenon is reversed by acute aggressive glycemic control. These findings provide a further rationale for use of insulin therapy in acute myocardial infarction and suggest its extension to ACS patients.