Validation Of Isolation Methodology And Endogenous Control Selection For Qrt-Pcr Assessment Of Microrna Expression In Serum And Urine Exosomes

Introduction: MicroRNAs are short RNA molecules that control ~50% of genes by binding to the mRNA 3’ UTR and repressing translation. Recently, they have been detected within exosomes; small vesicles secreted by most cells and abundant in body fluids. Exosomes are highly enriched for specific microRNAs and have been proposed as the starting point for circulating biomarker studies.