Mutation-Enhanced International Prognostic Scoring System (Mipss) For Primary Myelofibrosis: An Agimm & Iwg-Mrt Project
BLOOD(2014)
摘要
BACKGROUND. In primary myelofibrosis (PMF), survival from time of diagnosis is predicted by the international prognostic scoring system (IPSS), and from time of referral, by the dynamic IPSS (DIPSS) or DIPSS-plus. JAK2/CALR/MPL mutational status and presence and number of other prognostically-relevant mutations (ASXL1, SRSF2, EZH2, IDH1/2) provide IPSS/DIPSS-plus independent prognostic information. The objective in the current study was to revise IPSS, by including mutation-relevant prognostic information.
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关键词
primary myelofibrosis,mipss,mutation-enhanced,iwg-mrt
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