Selective elimination of isolectin B4-binding trigeminal neurons enhanced formalin-induced nocifensive behavior in the upper lip of rats and c-Fos expression in the trigeminal subnucleus caudalis
Neuroscience Research(2016)
摘要
•We examined the role of IB4+ non-peptidergic C-fibers in orofacial pain.•The IB4-Sap treatment decreased IB4+ terminals in the Vc and IB4+ TG neurons.•The IB4-Sap treatment increased formalin-induced FRB and c-Fos-IR cells in the Vc.•Systemic bicuculline and muscimol had decreasing effects on FRB and c-Fos-IR cells.•IB4+ neurons play antinociceptive roles that are modulated by GABAA functions.
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关键词
IB4,c-Fos,GABAA,Saporin,Formalin test
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