Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor

Yuko Shiba,Fumiaki Mori,Junko Yamada,Keisuke Migita,Yoshikazu Nikaido,Koichi Wakabayashi,Sunao Kaneko,Motohiro Okada,Shinichi Hirose,Shinya Ueno

Neuroscience Research（2015）

引用 17|浏览14

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摘要

•Rats with a missense mutation in the nicotinic receptor β2 subunit were generated.•V286L-TG showed spontaneous epileptic seizures, similar to human ADNFLE.•V286L-TG rats demonstrated hypersensitivity to nicotine administration.•V286L-TG may cause an imbalance of excitation versus inhibition leading to seizures.

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关键词

ADNFLE,EEG,nAChR,non-TG,PDGF,V286L-TG

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