Progressive increase of resistance of Plasmodium falciparum to amino-4-quinoleins in the Highlands of Madagascar

Bulletin De La Societe De Pathologie Exotique(1998)

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摘要
Malaria in Madagascar is one of the first causes of death and hospitalization and remains a real public health problem. Recent research proves that the resistance of the R III type, which is very widespread notably in Central Africa does not yet exist on the Island, even though a decrease in sensitivity of the Malgasy strains of Plasmodium falciparum has been reported. A surveillance of the sensitivity to the amino-4-quinoleins has been carried out since 1988 by the malaria laboratory of the Pasteur institute of Madagascar. Until recent years, the level of resistance had maintained itself at from 10 to 15 % of In vitro resistance (Ankazobe region) and from 10 to 35 % of parasitological failure on the seventh day of observation (simplified WHO test). The increase in value of the Cl90 in vitro of chloroquine was however alarming, although the clinical efficiency of chloroquine was constant. During the 1995-1996 period of transmission, a new set of tests was carried out in the region of Ankazobe and Moramanga. in both geographically separated zones of stable malaria, 92 isolates of Plasmodium falciparum were tested for their sensitivity in vitro to Chloroquine (CQ) using the method of the isotopic microtest based on the inhibition of the incorporation of tritium marked hypoxanthine. Out of the 85 isolates which matured well, 57 % were sensitive CQS (CI50<80nM); 25 % CQSR (80nM更多
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关键词
Plasmodium falciparum,amino-4-quinoleins,resistance,Madagascar
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