MRI FINDINGS INFORM NEURODEVELOPMENTAL OUTCOMES IN INDIVIDUALS WITH AGENESIS OF THE CORPUS CALLOSUM (ACC): ANALYSIS OF A PROSPECTIVE COHORT

Objectives: The phenotypic spectrum of ACC patients is quite broad, ranging from mild symptoms to severe neurodevelopmental impairment and intractable epilepsy. This variability limits the ability of clinicians to give accurate family planning advice and delays the design of appropriate therapy interventions. We sought to establish reliable correlations between MRI findings and clinical profiles in individuals with ACC with the goal of informing prognostic discussions and aiding therapeutic decisions.