The Esr1 Gene Polymorphisms In Patients With Coronary Artery Disease In The Southeastern Turkish Population

Aim: The objective of this study was to evaluate the prevalence of the estrogen receptor 1 (ESR1) gene variants and their possible association with coronary artery disease (CAD) in Sanliurfa province.Materials and methods: We used polymerase chain reaction and restriction enzyme digestion to determine the prevalence of the ESR1 gene (NM_001122742.1, GI: 2099): c.454-351 A>G (XbaI A>G) and c.454-397 T>C (PvuII T>C) polymorphisms in 100 healthy individuals and 80 angiographically confirmed CAD patients.Results: The body mass index (28.1 +/- 5.4), low-density lipoprotein cholesterol (126.1 +/- 42 mg/dL), diabetes (n = 13), and hypertension (n = 39) values of the CAD patients were significantly higher than in the control subjects (26.2 +/- 3.9, 106.1 +/- 26.3, 2, and 18, respectively) (P < 0.05). No significant differences were observed in the frequencies of both the c.454-351 A>G and c.454-397 T>C genotype of the ESR1 gene in CAD patients compared to healthy individuals (P > 0.05).Conclusion: The ESR1 variants tested in this study were not associated with CAD. Therefore, neither of these 2 variants can be considered as an independent risk factor or a predictor for CAD in the studied Turkish population.