Cutting in on a secretase pas de deux
Cell Research(2015)
摘要
Two proteolytic enzymes, β- and γ-secretases, work together to produce the amyloid β-peptide of Alzheimer's disease. New evidence suggests that these proteases directly interact and compounds that disrupt this interaction reduce amyloid β-peptide levels without directly blocking either enzyme's solo activity.
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关键词
Alzheimer's disease,Molecular neuroscience,Proteases,Proteolysis,Life Sciences,general,Cell Biology
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