Tracking of SDF-1+ and CXCR4+ cells in the ischemic heart utilizing novel (BAC)-EGFP reporter mice

Objective: Recently published data from our lab indicate that stabilization of the cardiac SDF-1/CXCR4 axis preserves myocardial function and attenuates ischemic cardiomyopathy. However, the basic mechanisms of SDF-1/CXCR4 mediated cellular repair are barely understood. Here, we aimed to track the fate of SDF-1+ and CXCR4+ cell populations in the bone marrow, peripheral blood and the heart under normoxaemic and ischemic conditions utilizing novel SDF-1 and CXCR4 (BAC)-EGFP reporter mice.