Dietary Fish Oil And Zinc Reduced Plasma Prostaglandin E-2 Content By Inhibiting Phospholipase A(2) Production In Broilers

Two-factor experiment was designed to examine from lipid metabolism, proinflammatory eicosanoids, and lipid peroxidation for investigating the effects of dietary oils and zinc levels of cardiovascular system of broilers. One hundred sixty 1-d-old male broilers were divided into 4 groups with 8 replicates of 5 birds fed one of the diets containing either corn oil or fish oil with one of 2 levels (75 mg/kg, 150 mg/kg) of zinc. Fish oil significantly decreased the levels of serum total cholesterol, triglyceride, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol of broilers, decreased the contents of plasma prostaglandin E-2, thromboxane B-2, and phospholipase A(2) in broilers when compared with corn oil. Zn level did not alter lipid metabolism, but significantly affected eicosanoid synthesis and lipid peroxidation of broilers. Zinc at 150 mg/kg significantly decreased the contents of plasma prostaglandin E-2, malondialdehyde, and phospholipase A(2) in broilers when compared to zinc at 75 mg/Kg. There were significant interactions between oil sources and zinc levels on production of serum triglyceride, high density lipoprotein-cholesterol, plasma 6-keto- prostaglandin F-1 alpha, phospholipase A(2) and malondialdehyde. In conclusion, fish oil improved lipid profiles, reduced proinflammatory eicosanoid contents by inhibiting phospholipase A(2) production in broilers; while zinc reduced the contents of plasma malondialdehyde, phospholipase A(2), and then decreased the concentration of prostaglandin E-2 of broilers.