The Circulating IGF System in Hepatocellular Carcinoma: The Impact of Liver Status and Treatment

Ulrick Espelund,Henning Grønbæk,Gerda Elisabeth Villadsen,Kira Simonsen,Poul Frølund Vestergaard,Jens Otto Lunde Jørgensen,Allan Flyvbjerg,Hendrik Vilstrup,Jan Frystyk

Growth Hormone & IGF Research（2015）

Cited 18|Views7

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Abstract

•HCC is a condition characterized by IGF-II overproduction•We therefore measured intact and pro-IGF-II in serum and well as IGF bioactivity in patients with HCC before and after treatment•HCC patients were compared with patients with liver cirrhosis patients and healthy controls•Our study showed that liver status has paramount effect on the circulating IGF-system, whereas the impact of HCC in much less•Thus, our data question the use of IGF-II as a marker of HCC.

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Key words

Hepatocellular carcinoma,Liver cirrhosis,Insulin-like growth factor II,Insulin-like growth factor I,Insulin-like growth factor binding proteins,Biological assay,Kinase receptor activation assay

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