Single Non-steroidal Anti-inflammatory Drug-Induced Hypersensitivity Reactions in Children: Case Report

Non-steroidal anti-inflammatory drug (NSAID) hypersensitivity is one of the most common drug-related reactions in children. According to European Network for Drug Allergy, NSAID hypersensitivity is mainly divided into two groups: single drug induced IgE or T cell-mediated reactions and cross-reactive reactions due to inhibition of cyclooxygenases. These major groups are classified in phenotypes according to the clinical findings and the presence of the underlying diseases. However, it may not sometimes be so easy to classify each patient according to these phenotypes. In this presentation, three children who had single NSAID-induced reactions but different clinical presentations have been described. Also, two of these children had some manifestations common to cross-reactive types of NSAID hypersensitivity which further complicated phenotyping.