Clinical and imaging markers in premotor LRRK2 G2019S mutation carriers
Parkinsonism & Related Disorders(2015)
Abstract
•We assess SN echogenicity and other echographic features in LRRK2 G2019S carriers.•We correlate echographic with clinical and imaging characteristics.•Asymptomatic LRRK2 mutation carriers had a higher frequency of SN+ than controls.•Asymptomatic LRRK2 mutation carriers had a larger area of SN echogenicity than controls.•The width of the third ventricle was significantly lower in LRRK2-PD than in IPD.
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Key words
Parkinson,LRRK2,Genetic,Transcranial ultrasound,Substantia nigra
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