Clinical and imaging markers in premotor LRRK2 G2019S mutation carriers

Dolores Vilas,Lourdes Ispierto,Ramiro Álvarez,Claustre Pont-Sunyer,María José Martí,Francesc Valldeoriola,Yaroslau Compta,Oriol de Fabregues,Jorge Hernández-Vara,Víctor Puente,Matilde Calopa,Serge Jaumà,Jaume Campdelacreu,Miquel Aguilar,Pilar Quílez,Pilar Casquero,Francisco Lomeña,José Ríos,Eduardo Tolosa

Parkinsonism & Related Disorders（2015）

Cited 35|Views20

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Abstract

•We assess SN echogenicity and other echographic features in LRRK2 G2019S carriers.•We correlate echographic with clinical and imaging characteristics.•Asymptomatic LRRK2 mutation carriers had a higher frequency of SN+ than controls.•Asymptomatic LRRK2 mutation carriers had a larger area of SN echogenicity than controls.•The width of the third ventricle was significantly lower in LRRK2-PD than in IPD.

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Key words

Parkinson,LRRK2,Genetic,Transcranial ultrasound,Substantia nigra

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