2-Aminobutyric Acid, a Potential Indicator of Oxidative Stress in Failing Hearts

Early diagnosis of heart failure (HF) remains difficult and identification of more sensitive biomarkers than conventional ones is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectrometry. We found the mean level of 2-Aminobutyric acid (2-AB) in ASD patients was significantly higher than that in healthy volunteers, and 1 month after transcatherter closure of ASD, serum 2-AB levels in patients decreased to almost the same levels as healthy volunteers.