Methyl-substitution of an Iminohydantoin Spiropiperidine Β-Secretase (BACE-1) Inhibitor Has a Profound Effect on Its Potency
Melissa Egbertson,Georgia B. McGaughey,Steven M. Pitzenberger,Shaun R. Stauffer,Craig A. Coburn,Shawn J. Stachel,Wenjin Yang,James C. Barrow,Lou Anne Neilson,Melody McWherter,Debra Perlow,Bruce Fahr,Sanjeev Munshi,Timothy J. Allison,Katharine Holloway,Harold G. Selnick,ZhiQiang Yang,John Swestock,Adam J. Simon,Sethu Sankaranarayanan,Dennis Colussi,Katherine Tugusheva,Ming-Tain Lai,Beth Pietrak, Shari Haugabook,Lixia Jin,I-W. Chen,Marie Holahan,Maria Stranieri-Michener,Jacquelynn J. Cook,Joseph Vacca,Samuel L. Graham Bioorganic & Medicinal Chemistry Letters（2015）
Key words
Amyloid,Beta secretase,Spiropiperidine,Magic methyl effect
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