Part 1: N-Alkylated Glycines As Potent Alpha(2)Delta Ligands

Lisa R. Thompson,David C. Blakemore,Delphine Brugier,Justin S. Bryans,Wai-Lam A. Chu,Graham N. Maw,Cedric Poinsard,David J. Rawson,Andrew N. Warren

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2011）

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摘要

A new series of glycine-derived ligands of the alpha(2)delta subunit of voltage gated calcium channels is described. Several novel compounds (7) based on (6) were prepared that possessed a potency <100 nM in the alpha(2)delta binding assay. (C) 2011 Elsevier Ltd. All rights reserved.

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关键词

alpha 2 delta, Gabapentin, N-Alkylated glycine, Amino acid

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