Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma

Christine E Brown,Behnam Badie,Michael E Barish,Lihong Weng,Julie R Ostberg,Wenchung Chang,Araceli Naranjo,Renate Starr,Jamie R Wagner, C L Wright,Yubo Zhai,James R Bading,Julie A Ressler,Jana Portnow,Massimo Dapuzzo,Stephen J Forman,Michael C Jensen

CLINICAL CANCER RESEARCH（2015）

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摘要

These findings provide promising first-in-human clinical experience for intracranial administration of IL13Rα2-specific CAR T cells for the treatment of GBM, establishing a foundation on which future refinements of adoptive CAR T-cell therapies can be applied.

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cd8+,antigen

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