Alterations of neuronal precursor cells in stages of human adult neurogenesis in heroin addicts

Ronald Bayer,Heike Franke,Christoph Ficker,Monique Richter,Rudiger Lessig,Andreas Buttner,Marco Weber

Drug and Alcohol Dependence（2015）

Cited 32|Views13

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Abstract

•The human hippocampus was examined using markers indicative of neuronal precursors.•Heroin addicts were compared to controls.•A decrease of precursor cells was detected in drug addicts.•Age-dependent increase of Musashi-1 expression is inhibited in addicts.•Drug addiction is associated with decreased calretinin fibre staining.

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Key words

Neurogenesis,Human,Drug abuse,Hippocampus,Heroin,Neural precursor cell

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