Mannich-type reaction of N,O-acetals with ketones mediated by a combination of TiCl4 and PhSiCl3

Osamu Onomura,Takashi Ikeda,Masami Kuriyama,Yoshihiro Matsumura,Satoshi Kamogawa

HETEROCYCLES（2010）

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摘要

A combination of TiCl4 and PhSiCl3 efficiently conducts the Mannich-type reaction of N,O-acetals with ketones to afford a-substituted cyclic amine derivatives in good yields. This method was applicable to preparation of azabicyclo compounds by the intramolecular Mannich-type reaction.

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关键词

Mannich-Type Reaction,Trichlorosilane,Titanium Tetrachloride,N,O-Acetal,Ketone

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