Efficient Synthesis Of 5-Amino-6-Dialkylamino-4-Hydroxypentanamide Derivatives For Renin Inhibitors

Yuji Nakamura,Yasuyuki Ogawa,Chie Suzuki,Teppei Fujimoto,Shojiro Miyazaki,Kazuhiko Tamaki,Takahide Nishi,Hiroshi Suemune

Heterocycles（2011）

引用 12|浏览4

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摘要

We report an efficient synthetic method for 5-amino-6-dialkylamino-4-hydroxypentanamide derivatives using Shi Asymmetric Epoxidation and the ring opening of N-(2-nitrobenzenesulfonyl)aziridine with hindered secondary amine as key steps.

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关键词

Asymmetric Synthesis,Aziridine,Epoxidation,Renin,Ring Opening

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