FIRST SYNTHESIS OF RACEMIC METHYLOPHIOPOGONANONE B AND ITS INHIBITORY ACTIVITY OF HYPOXIA-INDUCIBLE FACTOR-1 alpha

Mikio Fujii,Kiyoshi Egawa,Yasuaki Hirai,Masato Kondo,Hiroyuki Akita,Kiyoshi Nose,Kazuo Toriizuka,Yoshiteru Ida

Heterocycles（2009）

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摘要

Methylophiopogonanone B, a constituent of Ophiopogonis tuber, found to be a potent inhibitor of hypoxia induced factor-1 alpha (HIF-1 alpha) activity, was synthesized from 2,4,6-trihydroxy-3,5-dimethylacetophenone in 57% yield. The synthetic methylophiopogonanone B inhibited the reporter activity at 3 to 10 mu g/mL.

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关键词

Methylophiopogonanone B,Homoisoflavone,Ophiopogonis Tuber,HIF-1 alpha,Angiogenesis

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