Hydroxyalkylation-Initiated Radical Cyclization of N‑Allylbenzamide for Direct Construction of Isoquinolinone

A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction of N-allylbenzamide is developed. This reaction proceeds through C­(sp3)–H bond cleavage, oxyalkylation of the double bond, and intramolecular cyclization, which provides a new route toward 4-substituted 3,4-dihydroisoquinolin-1­(2H)-one derivatives.