Alkaline comet assay in liver and stomach, and micronucleus assay in bone marrow, from rats treated with 2-acetylaminofluorene, azidothymidine, cisplatin, or isobutyraldehyde

Andrew R Kraynak,John E Barnum, Cynthia Cunningham, Alex Ng, B A Ykoruk, B Bennet, D Stoffregen, M Merschman,Elizabeth Freeland,Sheila M Galloway

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

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摘要

•Validation studies of the in vivo rat alkaline comet assay in liver and stomach.•Studies coordinated by Japanese Center for the Validation of Alternative Methods.•2-Acetylaminofluorene, azidothymidine, cisplatin, and isobutyraldehyde, tested.•AZT, AAF, and CPN were positive in at least one tissue.•IBA was negative in both tissues.

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关键词

In vivo comet assay,JaCVAM validation study,Bone marrow micronucleus assay,2-Acetylaminofluorene (CASRN: 53-96-3),Azidothymidine (CASRN: 30516-87-1),Cisplatin (CASRN: 15663-27-1),Isobutyraldehyde (CASRN: 78-84-2)

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