Evaluation of p -phenylenediamine, o -phenylphenol sodium salt, and 2,4-diaminotoluene in the rat comet assay as part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay

Marlies De Boeck,Basjan Van Der Leede, Kathleen De Vlieger,Helena Geys,An Vynckier,Jacky Van Gompel

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

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摘要

•Three coded compounds were evaluated in the in vivo rat alkaline comet assay.•Contribution to JaCVAM comet assay validation trial in rat liver and stomach.•PPD and OPP were negative up to 100 and 1000mg/kg/day, respectively.•2,4-DAT (genotoxic carcinogen) was weak positive in liver and negative in stomach.

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In vivo comet assay,JaCVAM validation study,p-Phenylenediamine,o-Phenylphenol sodium salt,2,4-Diaminotoluene

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