Construction of a cytogenetic dose–response curve for low-dose range gamma-irradiation in human peripheral blood lymphocytes using three-color FISH
Mutation Research/Genetic Toxicology and Environmental Mutagenesis(2015)
摘要
•Chromosome aberrations induced in peripheral blood lymphocytes by irradiations were studied.•3-color FISH was conducted to score dicentrics and translocations.•A dose–response curve of gamma irradiations (0–300mGy) was constructed.•The dose–response curve provided a good fit to the linear-quadratic model.
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关键词
3-color FISH,Biodosimetry,Low-dose range,Gamma-ray irradiation,Dose response curve,Human peripheral lymphocytes
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