In vivo comet assay of acrylonitrile, 9-aminoacridine hydrochloride monohydrate and ethanol in rats

Yuzuki Nakagawa,Tomoyasu Toyoizumi,Hajime Sui,Ryo Ohta,Fumiaki Kumagai,Kenji Usumi,Yoshiaki Saito,Kohji Yamakage

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

引用 7|浏览19

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摘要

•Three coded compounds were evaluated in rats using the in vivo comet assay.•All genotoxic compounds induced DNA damage in liver cells.•The in vivo comet assay is a useful to evaluate the genotoxicity of chemicals.

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关键词

In vivo rat comet assay,JaCVAM validation study,Acrylonitrile,9-Aminoacridine hydrochloride monohydrate,Ethanol

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