Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 and CDK-4/Cyclin D1

Surovi Saikia,Bhaskor Kolita,P Dutta, Deep J Dutta, Neipihoi,S Nath,Manobjyoti Bordoloi,Pham Minh Quan,Tran Thu Thuy,Doan Lan Phuong,Pham Quoc Long

Steroids（2015）

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摘要

•In silico screening of star fish steroids against Bcl-2 and CDK-4/Cyclin D1.•Their physico-chemical, drug-likeliness and ADMET properties were determined.•Their binding affinity with Bcl-2 and CDK-4/Cyclin D1 were determined.•Two steroids have excellent potential against various cancer types.

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关键词

Echinoderms,Marine steroids,Anticancer drug candidate,Bcl-2,CDK-4/Cyclin D1,Docking

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