An epigenomic role of Fe65 in the cellular response to DNA damage

•Genotoxic stress promotes the recruitment of Fe65 on promoter of DNA damage responsive genes.•Fe65 target genes are functionally related to pathways of DNA damage response.•Motif analysis of ChIP-seq binding sites identified p53, E2F1, and Jun as co-regulators of Fe65.•248 genes differentially expressed upon stress were identified as Fe65 transcriptional targets.•Alteration in Fe65 expression level might lead to compromised DNA repair and cell survival.