Syntheses of deuterium‐labelled cholesteryl neoglycolipids

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS(2012)

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摘要
Four deuterium-labelled neoglycolipids derived from cholesterol were synthesized for embedment into liposomes. Deuterium atoms were either incorporated by CH2 replacement with a CD2 group in the triethylene glycol spacer arm between the cholesteryl residue and the sugar moiety (products 24) or incorporated directly on the acetamido function in the sugar head (compound 5).
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关键词
neoglycolipids,deuterium,N-acetyl-D-glucosamine,glycosylation,hydrophobic anchor,isotopically labelled synthesis,deuterium
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