Association of Vitamin D Receptor Gene Polymorphisms and Osteoporosis in COPD Patient

SESSION TITLE: COPD Posters I SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM PURPOSE: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of osteoporosis. Although many studies have addressed the relationship between the vitamin D receptor (VDR) gene polymorphism and bone health, study with COPD patients is not done yet. We performed this study to investigate the association of VDR gene polymorphisms with BMD and other clinical parameters in COPD patients. METHODS: Two hundred COPD patients (180 men and 20 women) were included in this study. The genotypes of VDR were determined by Sanger sequencing with blood samples. The BMD of the lumbar vertebrae and femur neck were measured by dual-energy X-ray absorptiometry. Other clinical parameters were also checked. Haplotype study and multivariate analysis were also done. RESULTS: Osteoporosis group showed significantly more female, lower body mass index, more steroid use, lower forced expiratory volume in 1 second (FEV1) %, higher alkaline phosphatase and lower 25-hydroxyvitamin D compared with the normal BMD group. The ApaI polymorphism and haplotype baT and bAT were related with osteoporosis. Patients not carrying haplotype bAT showed significantly lower T-score at femur neck and related with osteoporosis (OR 2.78, 95% CI 1.20-6.48, p=0.018) after adjustment of confounders in dominant model. CONCLUSIONS: From our results, not carrying bAT haplotype may have more susceptibility to osteoporosis in COPD patients. CLINICAL IMPLICATIONS: Clinicians could pay more attention to the bone health, if patients with COPD are not carrying bAT haplotype. DISCLOSURE: The following authors have nothing to disclose: Seiwon Kim, Jongmin Lee, Jickhwan Ha, Shinyoung Kim, Hyeon Hui Kang, Jinwoo Kim, Hwasik Moon, Sang Haak Lee No Product/Research Disclosure Information