The Use Of Sildenafil In The Acute Treatment Of Patients With Severe Pulmonary Arterial Hypertension And Right Heart Failure

PURPOSE: The acute treatment of severe Pulmonary Arterial Hypertension (PAH) poses a therapeutic challenge. Immediate access to agents such as prostacyclin and endothelin receptor blockers (ERBs) is limited. Sildenafil has been shown to have a direct vasodilator effect in the pulmonary circulation. The goal of this study is to describe the treatment response to Sildenafil for unstable, WHO Class IV PAH patients.