Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1′- homo -3′-isoazanucleosides and evaluation of their anticancer activity

Racemic 1′-homo-3′-isoazanucleosides have been obtained by microwave-assisted 1,3-dipolar cycloaddition of 3,5-disubstituted proline derivative (±)-2 with different alkynes. The compounds obtained were evaluated for their cytotoxic activities in vitro against human breast carcinoma cell lines (MCF-7), human ovary carcinoma cell lines (A2780) and human lung carcinoma cell lines (NCI–H460).