Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2015)
摘要
Bronchopulmonary dysplasia (BPD) is one of the most common complications of prematurity, occurring in 30% of very low birth weight infants. The benefits of dietary intake of polyunsaturated fatty acids -3 (PUFA -3) during pregnancy or the perinatal period have been reported. The aim of this study was to assess the effects of maternal PUFA -3 supplementation on lung injuries in newborn rats exposed to prolonged hyperoxia. Pregnant female Wistar rats (n = 14) were fed a control diet (n = 2), a PUFA -6 diet (n = 6), or a PUFA -3 diet (n = 6), starting with the 14th gestation day. At Day 1, female and newborn rats (10 per female) were exposed to hyperoxia (O-2, n = 70) or to the ambient air (Air, n = 70). Six groups of newborns rats were obtained: PUFA -6/O-2 (n = 30), PUFA -6/air (n = 30), PUFA -3/O-2 (n = 30), PUFA -3/air (n = 30), control/O-2 (n = 10), and control/air (n = 10). After 10 days, lungs were removed for analysis of alveolarization and pulmonary vascular development. Survival rate was 100%. Hyperoxia reduced alveolarization and increased pulmonary vascular wall thickness in both control (n = 20) and PUFA -6 groups (n = 60). Maternal PUFA -3 supplementation prevented the decrease in alveolarization caused by hyperoxia (n = 30) compared to PUFA -6/O-2 (n = 30) or to the control/O-2 (n = 10), but did not significantly increase the thickness of the lung vascular wall. Therefore, maternal PUFA -3 supplementation may protect newborn rats from lung injuries induced by hyperoxia. In clinical settings, maternal PUFA -3 supplementation during pregnancy and during lactation may prevent BPD development after premature birth.
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关键词
PUFA omega-3,bronchopulmonary dysplasia,prematurity,diet
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