Synthesis, characterization, anticancer activity and DNA interaction studies of new 2-aminobenzothiazole complexes; crystal structure and DFT calculations of [Ag(Habt) 2 ]ClO 4

Synthesis and characterization of new complexes of 2-aminobenzothiazole (Habt), [M(Habt)3Cl]Cl, [M(L)(abt)]Cl (M(II)= Pd, Pt; L=bpy, phen), [Ir(Habt)3(H2O)Cl2]Cl, [Ru(Habt)3(H2O)Cl2], [Rh(Habt)3Cl3], [OsO2(Habt)2(OH)2], [Zn(bpy)(Habt)Cl]Cl, [Zn(PPh3)(Habt)2Cl]Cl, [Ag(Habt)2]ClO4, [Ag(L)(Habt)]ClO4 (L=bpy, phen, PPh3) and [Au(Habt)3Cl]Cl2 are reported. The crystal structure and DFT conformational analysis of [Ag(Habt)2]ClO4 are determined. The free Habt and some complexes have been tested as anti-cancer agents against human breast cancer (MDA-MB231) and human ovarian cancer (OVCAR-8) cell lines. DNA-binding properties of some of the reported complexes were studied using circular dichroism (CD) spectra.