Prognostic Significance of Glycoprotein 96 in Human Hepatocellular Carcinoma

Glycoprotein 96(gp96) is highly expressed in cancer tissues. Recent studies indicate the possible roles of gp96 in the development and progression of hepatocellular carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of gp96 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that gp96 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. Gp96 expression was significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.