Design, synthesis and biological activity of novel chalcone derivatives as anti-influenza agents

series of novel chalcone derivatives was designed and synthesized via a suitable synthetic strategy in good yields using commercially available 2-amino-4-nitrophenol as an initiator. The structures of the target compounds were confirmed by means of 1 H NMR, 13 C NMR and high-resolution mass spectrometry(HRMS). And the ability of the target compounds to inhibit influenza viruses was evaluated. These compounds showed moderate inhibitory activity against influenza A(H9N2 and H5N1) viruses. Within this series, compounds S 14 and S 15 with good potency(IC 50 =40.3―51.5 μmol/L) could be used as lead compounds in the future.