PReS-FINAL-2297: Atmospheric pollution: influence on disease activity in childhood-onset systemic lupus erythematosus patients

range increases of PM10 (25.2 μg/m 3 ), CO (0.8 μg/m 3 ), and NO2 (102 μg/m 3 ) were associated with increases of 1.74 (CI of 95% 1.28-2.39), 1.37 (CI 95% 1.12-1.67) and 1.11 (CI 95% 1.02-1.21) in the risk of SLEDA-2K score score>8), respectively, 13 days after the exposure to these pollutants. The four days PM10 cumulative effect (from lag13 to lag16) increased the risk of outburst of SLE in 65% (CI 95% 1.06- 2.75). In contrast, ozone and SO2 did not show a significant effect on the SLEDAI-2K score.