Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.
ACS medicinal chemistry letters(2016)
Abstract
The rapid advancement of a series of noncovalent inhibitors of T790M mutants of EGFR is discussed. The optimization of pyridone 1, a nonselective high-throughput screening hit, to potent molecules with high levels of selectivity over wtEGFR and the broader kinome is described herein.
MoreTranslated text
Key words
Mutant EGFR,T790M,noncovalent,pyridone
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined