Long non-coding RNA derived miR-205-5p modulates human endometrial cancer by targeting PTEN.

Objective: This study was to investigate the roles of IncRNA associated competitive endogenous RNAs (ceRNAs) network in the endometrial cancer (EC). Methods: StarbaseV2.0 online software was used to predict the most probable IncRNAs which contain miR-205-5p binding site and are competent to interact with miR-205-5p. Then, IncRNAs which had decreased expression in EC compared with normal endometrium and conformed to the polyadenylated characteristics of IncRNAs were selected and then IncRNAs associated with miR-205-5p-PTEN network were identified. Results: Two novel genes RP11-395G23.3 and LA16c-313D11.11 associated with endometrial cancer were identified and proved to be non-coding RNAs. They were more effective ceRNAs associated with the miR-205-5p-PTEN network. Conclusion: Our results suggest that IncRNAs harbor MREs (miRNA response elements) and play important roles in the post-transcriptional regulation in EC.