Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2

Lentivirus-based transgenic Macaca fascicularis monkeys are generated expressing the human MECP2 transgene in the brain, and they display behavioural alterations including changes in social interaction and increased anxiety; germline transmission of the transgene to the F 1 offspring is shown, and these monkeys also had an altered social interaction phenotype.