Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A 1 ( 1 ), A 2 ( 2 ), B ( 3 ), C ( 4 ), D ( 5 ), and E ( 6 ) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var . mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods. Of the known ones, cycloastragenol-3- O - β -D-glucopyranoside ( 7 ), astraverrucin II ( 8 ), cycloaraloside E ( 9 ), huangqiyenin A ( 10 ), and huangqiyenin B ( 11 ) were isolated from the species first. Meanwhile, compounds 1 – 3 , 5 – 9 , and aleksandroside I ( 12 ) showed inhibitory effects on triglyceride accumulation in HepG2 cells.