Genistein alleviates lead-induced neurotoxicity in vitro and in vivo: Involvement of multiple signaling pathways.
NeuroToxicology(2016)
摘要
•Genistein alleviates lead-induced decline in the spatial reference memory.•Genistein mitigates lead-induced neural injuries by inhibiting apoptosis action.•Genistein mitigates lead-induced oxidative stress by regulating Nrf2 protein.•Genistein mediates its protective effects by phosphorylation of Akt and MAPKs.•Genistein regulates lead-induced ROS generation via PKC-α and NF-κB.
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关键词
Akt,BLL,Bax,Bcl-2,CAT,GEN,ERK,GCI,Pb,MAPK,NAC,Nrf2,NF-κB,PKC -α,ROS,SOD
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