Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.

Fabrizio Micheli,Susanna Cremonesi, Teresa Semeraro,Luca Tarsi,Silvia Tomelleri,Paolo Cavanni,Beatrice Oliosi,Elisabetta Perdonà,Anna Sava,Laura Zonzini,Aldo Feriani,Simone Braggio,Christian A Heidbreder

Bioorganic & Medicinal Chemistry Letters（2016）

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摘要

A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.

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关键词

Dopamine,Antagonist,DA D3 receptor,7-TM,Morpholine

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