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The influence of dizocilpine on the reserpine-induced behavioral and neurobiological changes in rats.

Zhen-Yong Gao,Ping Yang,Qing-Jun Huang,Hai-Yun Xu

Neuroscience Letters（2016）

Cited 12|Views5
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Abstract
•A single high dose of reserpine induced depressive symptoms in rats.•It also decreased hippocampal BDNF levels and hippocampal neurogenesis, but increased levels of GluN1 subunit.•Pretreatment of dizocilpine blocked or ameliorated all the reserpine-induced changes except for GluN1 subunit.
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Key words
Antidepressant,NMDA receptor,BDNF,Neurogenesis
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