A pilot study of an individualized comprehensive treatment for advanced gastric cancer with para-aortic lymph node metastasis
BMC gastroenterology(2016)
Abstract
Background The incidence of the para-aortic lymph node metastasis (PALM) in patients with advanced gastric cancer is 6 to 33 %. The prognosis is poor and the 5-year survival rate is only 12 to 23 % after gastrectomy with super-extended lymph node dissection. We applied an individualized comprehensive treatment for affected patients including neoadjuvant chemotherapy via intra-arterial and intravenous administration, surgery and radiotherapy, to investigate the safety and prognostic value. Methods Between January 2005 and December 2010, 47 advanced gastric cancer patients with PALM received 5-Fu (370 mg/m 2 ) and leucovorin (200 mg/m 2 ) intravenously on days 1–5, and intra-arterial infusion of etoposide (80 mg/m 2 ) and oxaliplatin (80 mg/m 2 ) on days 6 and 20, repeated 2 cycles. Patients achieved PR or CR of the para-aortic lymph node (PAL) were performed D2 dissection, followed by 6 cycles chemotherapy with XELOX regimen, oxaliplatin (130 mg/m 2 ) on day 1 and xeloda (1000 mg/m 2 ) on days 1 to 14 of a 28-day cycle, and radiotherapy to the region of PALM. Results Forty-six patients completed 2 cycles of neoadjuvant chemotherapy. The overall response rate of the primary tumor was 80.4 % (37/46). The response rate of PAL was 76.1 % (35/46). Thirty-two patients underwent D2 dissection and six cases achieved pathological complete response (pCR). The toxicity profile was well tolerable and there was no treatment-related death. The median survival time for all patients was 23 months, and for nonsurgical and surgical patients were 12 and 29 months ( p < 0.001), respectively. The 1-year, 2-year and 3-year survival rate was 70.96, 43.27 and 35.48 % for all patients, and for surgical patients was 96.875, 68.75, and 40.63 %. Conclusion Advanced gastric cancer patients with PALM can obtain a survival benefit from neoadjuvant chemotherapy, subsequent surgery and radiotherapy. Trial registration Current Controlled Trials ChiCTR-TRC-12002046 .
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Key words
Advanced gastric cancer,Neoadjuvant chemotherapy,Intravenous and intra-arterial administration,D2 dissection,Radiotherapy
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