Toxocara canis: Larvicidal activity of fatty acid amides.
Bioorganic & Medicinal Chemistry Letters(2016)
Abstract
Considering the therapeutic potential of fatty acid amides, the present study aimed to evaluate their in vitro activity against Toxocara canis larvae and their cytotoxicity for the first time. Linoleylpyrrolidilamide was the most potent, with a minimal larvicidal concentration (MLC) of 0.05mg/mL and 27% cytotoxicity against murine peritoneal macrophages C57BL/6 mice, as assessed by the MTT assay.
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Key words
Toxocarosis,Chemotherapy,Cytotoxicity,Chemical compounds
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