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Super-paramagnetic loaded nanoparticles based on biological macromolecules for in vivo targeted MR imaging

Chutimon Sanjai,Suchart Kothan,Pattarapond Gonil,Somsak Saesoo,Warayuth Sajomsang

International Journal of Biological Macromolecules（2016）

Cited 10|Views7
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Abstract
⿢SPIONPs-CS-FA was prepared by using an ionotropic gelation method.⿢SPIONPs-CS-FA showed low cytotoxicity and high water stability.⿢SPIONP-CS-FA showed decrease in signal intensity in both T2W and T2*W images.⿢SPIONP-CS-FA showed in vitro cellular uptake by targeting folate receptors.⿢SPIONP-CS-FA can be used as an either tumor or organ specific MRI contrast agents.
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Key words
Chitosan,Chitosan-folic acid nanoparticles,Super-paramagnetic iron oxide,Ionotropic gelation,Magnetic resonance imaging (MRI)
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